Immunodynamics of Th17 cells in HIV-1 subtype ‘C’ infection
نویسندگان
چکیده
Methods 31 HIV seropositive antiretroviral therapy naïve and 8 HIV uninfected healthy control subjects were recruited and characterized as being early, late or slow progressor. Peripheral blood mononuclear cells were isolated from each study subject and stimulated with HIV-1 subtype ‘C’ gag peptide pool and assessed for IL-17 cytokine producing CD4-T cells using intracellular cytokine staining. All clinical groups were statistically compared by Kruskal-Wallis test and Spearman’s correlation coefficient was calculated for correlation of different variables.
منابع مشابه
Mucosal Immunol
Loss of CD4(+) T cells in the gut is necessary but not sufficient to cause AIDS in animal models, raising the possibility that a differential loss of CD4(+) T-cell subtypes may be important. We found that CD4(+) T cells that produce interleukin (IL)-17, a recently identified lineage of effector CD4(+) T-helper cells, are infected by SIV(mac251)in vitro and in vivo, and are found at lower freque...
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